About Our Research: Our Theoretical Biophysics Lab studies the physical principles that govern the response of cells to the mechanical properties of their environment. Using elasticity theory and principles of statistical physics and active matter physics, we investigate fundamental biological phenomena such as the establishment of cell morphology and structure, the emergence of elastic interactions between cells, patterning, aggregation and alignment of cells. Using computer simulations, we also investigate the interactions of motor proteins and filaments in the cell cytoskeleton that generate forces and movements in cells, for instance during cell motility and neuron growth and differentiation.
Job Description: We have openings for PhD students to work on a diverse range of research topics within our group. Specific projects include:
(i) Development of physics-based models of cell mechano-sensitivity: The cells in our body are contractile; they use molecular motors to generate forces that, among other things, enable them to sense and respond to the physical properties of their environment, including the surrounding stiffness and elastic deformations resulting from other cells’ forces. Such cues play vital roles in the regulation of cell behavior and fate. Our aim is to obtain a fundamental understanding of how cells mechanically sense their environment and mechanically communicate with each other, to explain a variety of cell behaviors including the establishment of cell morphology and the emergence of complex multicellular organization from simple mechanical interactions.
(ii) Development of computer simulations of neuron growth: Brain function depends on precise yet highly dynamic connectivity between neurons. Mechanical forces and environmental cues are now recognized as key regulators of neuronal growth, guidance, and development. We develop molecular-level computer simulations of motor proteins and other cytoskeletal components to investigate how intracellular force generation and transport drive neuronal growth and development.
Our research is carried out in close collaboration with leading experimental groups throughout the world, providing opportunities to connect theoretical predictions with experimental observations.
Please note: Candidates who meet the listed criteria (see below) but have related research interests are encouraged to get in touch. Additional positions may be available for strong candidates, and the PI would be pleased to discuss potential opportunities.
Your Profile (To excel in this role, we seek candidates who):
- Are curious about both biology and physics, and motivated to develop and rigorously explore theoretical models to elucidate fundamental principles that govern biological phenomena.
- Have strong background in physics and have a BSc and/or MSc degree in either Physics, Physical Chemistry, Computer Science, Mechanical- or Bio-engineering, or a related field.
- Are motivated to work in a collaborative, interdisciplinary, and international research environment.
- Have an excellent command of English.
Funding: Suitable candidates will be offered full scholarship for a period of four years.
Application: Please submit your application as three separate PDFs, each containing the following:
- Letter of motivation
- CV (including a list of publications)
- Copy of your original academic degree(s) and transcripts
Application Deadline: See details below
About Your Supervisor: Dr. Assaf Zemel is a theoretical biophysicist. He obtained his Ph.D. in theoretical chemistry from the Hebrew University of Jerusalem and then moved into the field of cell mechanics through postdoctoral training at the Weizmann Institute of Science and the University of California, Davis. Since 2008, Dr. Zemel has headed the Theoretical Biophysics Lab at the Institute of Biomedical and Oral Research of the Hebrew University and has been a faculty member at the Fritz Haber Research Center for Molecular Dynamics.
About Our Campus: Hebrew University’s medicinal campus is situated in southwestern Jerusalem, on the picturesque Ein Kerem campus. The Ein Kerem campus is a hub for cutting-edge medical education and research in Jerusalem. Located next to Hadassah Hospital - a world-renowned medical center - it brings together top programs in Medicine, Dentistry, Pharmacology, Nursing, Occupational Therapy, and Public Health, and plays a central role in shaping the next generation of healthcare professionals and researchers
Embracing Diversity: At Hebrew University we believe that diversity inspires creativity, fosters curiosity, and enriches our ecosystem through academic collaboration and cultural exchange. We consider every member of our community an integral part, irrespective of their religion, gender, or ethnic origin.
The University is home to nearly 25,000 students across our 6 campuses, including ~2,500 international students per year representing 90+ countries. You’ll enjoy the opportunity to engage with your peers here on equal ground, in an environment that promotes equity and inclusion, and celebrates the contribution of its talented members.
About Hebrew University: The Hebrew University of Jerusalem (HUJI) is one of the world's leading research institutions, consistently ranked as a global top 100 university. Established by luminaries such as Albert Einstein, the University is at the forefront of groundbreaking research, entrepreneurship, and innovation across various domains, including brain sciences, medicine, biomedicine, life sciences, mathematics, agriculture, and more. Our 6 campuses house 100+ research centers, with ~4,000 research projects underway year-round.
About Jerusalem: Hebrew University is an integral part of Jerusalem, Israel’s capital and one of the most fascinating, diverse cities on earth. Thousands of students from across the globe live in Jerusalem, immersing themselves in its vibrant cultural and culinary scenes, while marveling at the juxtaposition of its 3,000-year-old history and cutting-edge modernity. Students make the most of their spare time by enjoying Jerusalem’s myriad attractions, from restaurants, cafes and pubs, to dance clubs, museums, theaters, and year-round festivals.
