Location: The Francis Crick Institute, Midland Road, London
Contract: Fixed-term (4 years), Full time
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 7304
An exciting opportunity to be part of a pioneering biomedical research institute, dedicated to innovation and science. A Postdoctoral Training Fellow post for someone skilled in computational biology is now available in the laboratory of Jean Langhorne.
Dr Langhorne’s laboratory focuses on immune responses to malaria in humans and experimental models, their regulation and their role in pathogenesis of malaria. Details of research projects currently being undertaken can be seen at www.crick.ac.uk/jean-langhorne. We are looking for a highly motivated researcher to join a team investigating immune signatures of children with differing susceptibility to malaria.
This project aims to understand the human immune response to Plasmodium falciparum and will be part of a large collaborative research programme funded by the MRC. The study will investigate features that distinguish immune responses of children with frequent symptomatic P. falciparum infections. Recent technological advances in flow cytometry, RNA seq, multiplexing for cytokine response, as well as the widespread intensive use of flow cytometry in research and clinical settings have resulted in large data sets of increasing complexity that require novel approaches for analysis and data management. A part of the project will be involved in analysing high dimensional Flow Cytometry data analysis (CyTOF and standard Flow data, but will also include integrating several large data sets of RNA seq, cytokine measurements and antibody responses. The analyst will work collaboratively with other members of the consortium using existing publicly available and commercial software solutions, and in some cases develop novel tools using statistics, mathematics and machine learning approaches for the analysis of high dimensional biological/biomedical/epidemiological data.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.