Postdoctoral research on the role of oxygen in T cells

Do you want to contribute to top quality medical research?

The research group

Our group works on the relationships between oxygen flux and tissue function, physiology and pathology. We have in recent years focused on how immune cells, and in particular T cells, are influenced by oxygen. We have used our findings to increase the immunotherapeutic efficacy of T cells in cancer models and are extending these exciting findings in our current work.

Your mission

The project focusses on how tissue and immune cell generated metabolites influence T cell fate. The metabolites we are interested in are chiefly but not exclusively regulated by oxygen and the HIF pathway of hypoxic response. The project will build on observations of effects on in vivo immunotherapeutic efficacy through immunometabolite administration.

Your profile

To be eligible for employment as a postdoctor a Ph.D or a foreign degree deemed to be equivalent to a Swedish Ph.D is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are in particular interested in candidates with graduate level expertise and training in immunology. Experience with cytotoxic (CD8+) T cell culture and experimental procedures in both murine and human systems would be of the greatest interest.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Stockholm

--- [Video about a Karolinska Institutet, how we work towards "a better health for all"] --

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply!

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

1. Prof. Randall Johnson, randall.johnson@ki.se

1. Shahla Rostami, OFR, shahla.rostami@ki.se
2. Björn Andersson, SACO, bjorn.andersson@ki.se
3. Elisabeth Valenzuela, SEKO, elisabeth.valenzuela@ki.se