We welcome applications for a PhD position within the project “Bioengineering artificial extremozymes and ‘extremocells’ for robust and sustainable biocatalysis” as part of an Ambizione Grant funded by the Swiss National Science Foundation. The successful candidate will work directly under the supervision of the Ambizione grantee, Dr. Ana I. Benítez-Mateos. 

Enzyme catalysis is gaining momentum as a highly selective and sustainable strategy to synthesize pharmaceuticals, fragrance molecules, or food additives. However, biocatalysts are not adapted to the non-natural conditions to which they are exposed during reactions. Hence, they suffer from low stability which impacts their cost-efficiency.

In this project, we aim to develop a novel protein bioengineering technology to develop robust and efficient biocatalysts, with the potential to become a universal tool to transform any enzyme/cell into a more efficient biocatalyst. In reaching its goals, this project will not only consolidate but also expand the role of biocatalysis in industry, biomedicine, and biotechnology towards a more sustainable society.

A full-time position for 4 years starting immediately or upon mutual agreement (between mid-October and November 2024). You will work in an interdisciplinary laboratory of researchers with strong expertise in Biocatalysis and Intrinsically Disordered Proteins. Furthermore, collaborations with well-known researchers from Switzerland, UK, Germany, and USA are planned. Throughout the project there will be mentoring opportunities, including bachelor and master students’ projects. You will actively participate in group and institute duties as well as teaching activities. As an integral part of your work, you will publish your results in peer-reviewed journals and present them at (inter)national conferences.

The position will be mainly based in the Biochemical Engineering Laboratory (headed by Prof. P. Arosio) at the Department of Chemistry and Applied Biosciences at ETH Zurich, Switzerland. Moreover, the candidate will spend 1-2 years (to be determined) at the Technical University of Munich, Germany.

• Master’s degree in Biology, (Bio)chemistry, Biotechnology, Chemical/Bioengineering, or related disciplines from a recognized university.
• Excellent track-record and meet the general admission requirements for a doctorate at ETH Zurich.
• Proficiency in English, good communication skills, and social competence are required.
• High self-motivation with commitment to scientific excellence and willingness to travel.

You will be part of a young, enthusiastic, and dynamic research team with a strong background in Biocatalysis. You will have access to state-of-the-art facilities and will become part of the PhD. Moreover, you will be involved in mentoring activities, receive support for career development, and participate in science outreach.

ETH Zurich is an employer with excellent working conditions. You can look forward to an exciting working environment, cultural diversity, and attractive offers and benefits together with world-leading infrastructure and facilities. We promote equality of opportunity, value diversity, and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected.

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

We look forward to receiving your online application with the following documents:

• Curriculum vitae (max. 2 pages)
• Copies of BSc and MSc educational records
• Motivation letter (max. 1 page)
• Names and contact details of 1-2 references

Applications will be reviewed on a rolling basis, and the position will be filled as soon as a suitable candidate is identified. Questions regarding the position should be directed to Dr. Ana I. Benítez-Mateos, email: ana.benitez-mateos@chem.ethz.ch. For more details about our research, visit our website.

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.